Document Type
Article
Publication Date
10-2014
Abstract
Calcium-mediated signals play important roles inepidermal barrier formation, skin homoeostasis and wound repair.Calmodulin 4 (Calm4) is a small, Ca2+-binding protein withstrong expression in suprabasal keratinocytes. In mice, Calm4 firstappears in the skin at the time of barrier formation, and itsexpression increases in response to epidermal barrier challenges.In this study, we report the generation of Calm4 knockout miceand provide evidence that Calm4 is dispensable for epidermalbarrier formation, maintenance and repair.
Recommended Citation
Lessard JC, Kalinin A, Bible PW, Morasso MI. Calmodulin 4 is dispensable for epidermal barrier formation and wound healing in mice. Exp Dermatol. 2014 Oct 15. doi: 10.1111/exd.12568.
