Document Type


Publication Date

Fall 2021


Tumor heterogeneity presents a significant barrier to glioblastoma treatment. While multiparametric imaging can improve characterization of such heterogeneity, advances have been limited by access to ground truth pathology and genomics. Stereotactic localization addresses the former issue, allowing pairing of biopsy location with corresponding voxels in MR image. Using stereotactic localization, as well as voxelwise MR image analysis, a feedforward dense network, and whole-exome sequencing, the authors sought to improve multiparametric MR characterization of tumor heterogeneity.


Indiana University Health Supervisors: Dr. Jason Parker, Masha Servati, Haley Trussell, Emily Diller



To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.