Document Type
Poster
Publication Date
Fall 10-6-2022
Abstract
Appropriate levels of an active pharmaceutical ingredient (API) in medicines must be present in a medical product for the patient to receive therapeutic value. High performance liquid chromatography (HPLC) was used to develop a methodology to test for the API in Ampicillin and Cefuroxime drugs. Following the regulations of the Distributed Pharmaceutical Analysis Lab (DPAL) out of Notre Dame system sustainability requirements linearity, precision, accuracy/range, spike/degraded spike, limit of detection /quantitation, tailing factor, and number of theoretical plates were experimentally determined to meet the excepted standards.
Recommended Citation
McInerney, Patrick and Martoglio, Richard, "High Performance Liquid Chromatography (HPLC) for Ampicillin and Cefuroxime" (2022). Annual Student Research Poster Session. 108, Scholarly and Creative Work from DePauw University.
https://scholarship.depauw.edu/srfposters/108
Comments
The ampicillin methodology is finished and ready to be submitted to DPAL for verification. For Cefuroxime, the spikes need to be completed.
Source of Funding: Science Research Fellows program, the Larry and Lesley Stimpert Endowed Fund for Student-Faculty Research and the Student-Faculty Collaborative Research Fund.