Pyrrolidine Derivative Targets Actin Cytoskeleton in MCF-7 Breast Cancer Cells

Authors

An Pham, DePauw University
Jeff Hansen, DePauw University
Sarah Mordan-McCombs, DePauw University

Files

Document Type

Poster

Publication Date

Fall 10-6-2023

Abstract

Recent research has brought pyrrolidine derivatives into consideration for the development of anticancer drugs with high efficacy and low toxicity. Dr. Hansen’s lab at DePauw has synthesized a pyrrolidine derivative that demonstrated anticancer activity. However, there are many ways a compound can affect cancer cells. In this research, we decided to investigate the mechanism of action of this new compound, specifically on MCF-7 breast cancer cell line. Based on the results, we believe that there is a great likelihood that the pyrrolidine derivative can induce apoptosis (cell death) and disrupt cell movement in MCF-7 cells. In other words, these are strong indicators that this compound can inhibit both early and late-stage cancer cells.

Department

Biology, DePauw University

Project Mentor

Jeff Hansen, PhD, and Sarah Mordan-McCombs, PhD

Funding and Acknowledgements

Funding provided by the J. William Asher and Melanie J. Norton Endowed Fund in the Sciences

Recommended Citation

Pham, An; Hansen, Jeff; and Mordan-McCombs, Sarah, "Pyrrolidine Derivative Targets Actin Cytoskeleton in MCF-7 Breast Cancer Cells" (2023). Annual Student Research Poster Session. 127.
https://scholarship.depauw.edu/srfposters/127