Recent research has brought pyrrolidine derivatives into consideration for the development of anticancer drugs with high efficacy and low toxicity. Dr. Hansen’s lab at DePauw has synthesized a pyrrolidine derivative that demonstrated anticancer activity. However, there are many ways a compound can affect cancer cells. In this research, we decided to investigate the mechanism of action of this new compound, specifically on MCF-7 breast cancer cell line. Based on the results, we believe that there is a great likelihood that the pyrrolidine derivative can induce apoptosis (cell death) and disrupt cell movement in MCF-7 cells. In other words, these are strong indicators that this compound can inhibit both early and late-stage cancer cells.
Pham, An; Hansen, Jeff; and Mordan-McCombs, Sarah, "Pyrrolidine Derivative Targets Actin Cytoskeleton in MCF-7 Breast Cancer Cells" (2023). Annual Student Research Poster Session. 127, Scholarly and Creative Work from DePauw University.