Acetalization of Amino Alcohols Derived from Ring Opening Reactions of Epoxide

Authors

Kaylee Nichols, DePauw University

Files

Document Type

Abstract

Publication Date

10-2-2019

Abstract

Epoxides are classified as ethers that contain two partially positive carbon atoms connected to a Lewis-Base oxygen that form a ring. The reaction conditions for forming an epoxide compound from chlorobenzaldehyde and cyclohexanone, and the reaction conditions for opening the epoxide ring using amino alcohols are well-known in Professor Hansen’s lab thanks to previous research. Therefore, the goal of this project was to first open the epoxide ring using an amino alcohol and then form an acetal. The idea was this acetal would then be biologically active, tested using the BSLA, and potentially have pharmaceutical applications. After trying several different reaction conditions, we were unsuccessful in creating the desired acetal product according to NMR results. Further literature research will be done in attempt to find a set of reaction conditions that will result in the formation of the acetal.

Project Mentor

Prof. D. Harvey, PhD

Funding and Acknowledgements

Funding: Elliott Morrill Research Fund

Recommended Citation

Nichols, Kaylee, "Acetalization of Amino Alcohols Derived from Ring Opening Reactions of Epoxide" (2019). Annual Student Research Poster Session. 176.
https://scholarship.depauw.edu/srfposters/176