Acetal Formation from an Alcohol Epoxide

Acetal Formation from an Alcohol Epoxide

Document Type

Abstract

Publication Date

10-2-2019

Abstract

Organic synthesis is the backbone for the discovery of new drugs. The goal of our lab is to create new organic, biologically active compounds to be used in pharmaceutical research. In our lab, we start with the creation of an epoxide molecule that we are able to make in large quantities. Each member of the research team started their reactions with the epoxide molecule and tried to combine it with an active nucleophile. For my experiment, I used an enolate and an enamine to attack the carbon of the epoxide ring. An enolate was generated using a cyclohexaone and kept under certain conditions. 1- pyrrolidino-1-cyclohexene was used as an enamine nucleophile. These two reactions were designed to create an acetal with the epoxide molecule. The chosen nucleophiles did not create the acetal as expected. Further research into the formation of an acetal includes looking into different nucleophiles and the addition of a protecting group.

Project Mentor

Prof. J. Hansen, PhD

Funding and Acknowledgements

Funding: Howard and Lucile Burkett Endowed Research Fund

Acetal Formation from an Alcohol Epoxide

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