Adamts6 Function is Crucial for Skeletal Development in Mice
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Document Type
Abstract
Publication Date
10-2-2019
Abstract
ADAMTS (A Disintegrin-like and Metalloproteinase with Thrombospondin type 1 motifs) proteins are secreted, extracellular matrix (ECM)-associated metalloproteinases. There are 19 ADAMTS protein-coding genes in mammals. Among them is Adamts6, which is often referred to as an orphan enzyme. Interestingly, the Adamts6 mutant mice generated in our laboratory are associated with craniofacial and heart defects as well as significant skeletal anomalies. In this study, we attempted to uncover the molecular and cellular mechanisms underlying the morphological defects by examining the patterns of expression of known molecular markers of cartilage and bone development. We found that the skeletal developmental defects in Adamts6 mutant mouse embryos were associated with impairment of regional cell proliferation and differentiation.
Department
University of Cincinnati - Cincinnati Children's Hospital Medical Center, Department of Developmental Biology, Division of Plastic Surgery
Project Mentor
Dr. Yu Lan
Recommended Citation
Black, Morgan, "Adamts6 Function is Crucial for Skeletal Development in Mice" (2019). Annual Student Research Poster Session. 194.
https://scholarship.depauw.edu/srfposters/194
Funding and Acknowledgements
Funding: NIH Grant