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Document Type
Poster
Publication Date
Fall 10-1-2026
Abstract
The vertebrate eye develops through a series of coordinated events that transform the early optic vesicle into the optic cup, the structure that eventually gives rise to the retina and other essential components of the eye. Proper optic cup morphogenesis depends on precise interactions between developing eye tissues, surrounding cells, and the extracellular matrix. Disruptions in these interactions can interfere with normal eye formation, making it important to better understand the molecular mechanisms that regulate cellular interactions during optic cup formation. The basement membrane is a type of extracellular matrix that provides structural support and helps regulate cell behavior during eye development, specifically in the formation of the optic cup. Previous studies have shown that nidogen, a component of the basement membrane, is expressed by periocular neural crest cells during optic cup development [1]. However, nidogen is only one of many proteins that make up the basement membrane. Therefore, the purpose of this study is to determine which additional basement membrane components are also expressed by neural crest cells during early eye development.
Department
Division of Ophthalmology, Ann & Robert H. Lurie Children's Hospital of Chicago, IL ; Department of Ophthalmology, Northwestern Feinberg School of Medicine, Chicago, IL
Project Mentor
Antionette L. Williams, PhD, and Brenda L. Bohnsack MD, PhD
Recommended Citation
Chavez-Corzo, Daniela '27; Williams, Antionette L.; and Bohnsack, Brenda L., "Perlecan deopisiton by Sox10+ periocular neural crest cells during early eye development in zebrafish" (2026). Annual Student Research Poster Session. 251.
https://scholarship.depauw.edu/srfposters/251
Funding and Acknowledgements
Robert Louis Katz & Manne Research Institute Summer Scholars Program through Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago