Opening of an Epoxide Ring Using Azide to Form a Triazole

Authors

Emily Hufnagel, DePauw University
Jeffrey A. Hansen, DePauw UniversityFollow

Files

Document Type

Poster

Publication Date

Fall 10-2-2019

Abstract

The purpose of this research project is to identify and synthesize biologically active compounds that could potentially aid in pharmaceutical research. Once a compound is correctly identified and purified, the sample can be diluted and added to a Brine Shrimp Lethality Assay in order to determine the toxicity of the compound. This experiment was designed using an epoxide compound to form an azide that would eventually form a triazole. In carrying out this project, two main procedures were used in order to create two different compounds that would eventually create the final result. The triazole was not successful in the BSLA and the concentration was not able to be increased due to the solubility of the compound. With further research, the azide compound the azide compound can continue to be utilized in order to create other potentially biologically active compounds.

Funding and Acknowledgements

Funding: Elliott Morrill Research Fund

Recommended Citation

Hufnagel, Emily and Jeffrey A. Hansen. "Opening of an Epoxide Ring Using Azide to Form a Triazole." Poster presented at the DePauw University Science Research Fellows Poster Session, Greencastle, IN, October 2019.