T Helper 17 (Th17) cell-driven neutrophilic asthma is a rare, yet severe phenotype that accounts for over 75% of all asthma related medical costs. Neural innervation has been known play a role in the immune response and we investigated whether the addition of neurotransmitters to would affect Th17 cell differentiation. Results indicated that neural innervation upregulated Th17 cell differentiation and expression of its cytokine IL-17 that is responsible for the severe symptoms seen in neutrophilic asthma.
Cowger, Kate; Wang, Wei PhD; and Ai, Xingbin PhD, "Neural Innervation of the Immune Response Could Lead to Treatments for Severe Asthma: The Screening of Neurotransmitters on T Helper 17 Cell Differentiation" (2021). Annual Student Research Poster Session. 61, Scholarly and Creative Work from DePauw University.