Document Type


Publication Date

Summer 2021


T Helper 17 (Th17) cell-driven neutrophilic asthma is a rare, yet severe phenotype that accounts for over 75% of all asthma related medical costs. Neural innervation has been known play a role in the immune response and we investigated whether the addition of neurotransmitters to would affect Th17 cell differentiation. Results indicated that neural innervation upregulated Th17 cell differentiation and expression of its cytokine IL-17 that is responsible for the severe symptoms seen in neutrophilic asthma.


Thank you to Dr. Xingbin Ai, Dr. Wei Wang, and Dr. Bryan Hurley Neonatology Department, Massachusetts General Hospital
Dr. Robert West, Psychology and Neuroscience Department, DePauw University

Funding: National Institutes of Health