Specific Metabolic Pathways Regulate Inflammation in Metabolic Dysfunction-Associated Steatotic Liver Disease

Specific Metabolic Pathways Regulate Inflammation in Metabolic Dysfunction-Associated Steatotic Liver Disease

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Document Type

Poster

Publication Date

10-1-2025

Abstract

Metabolic dysfunction-associated steatotic liver disease (MASLD) is becoming increasingly prevalent worldwide. Yet, the knowledge of disease mechanisms and available therapies are highly limited. To better understand the disease and provide potential treatments, our lab utilized various mice and in vitro models in order to determine how specific metabolic pathways impact disease progression. Combined, our findings and prior work in the lab provide novel insights for potential predictive, preventive, and therapeutic avenues.

Department

Department of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio

Project Mentor

Keisuke Sawada and Senad Divanovic

Funding and Acknowledgements

National Institute of Health, American Diabetes Association, American Heart Association, and CCHMC Albert B. Sabin Fellowship

Specific Metabolic Pathways Regulate Inflammation in Metabolic Dysfunction-Associated Steatotic Liver Disease

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